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ESTScan 3.0.3

Company: Christian Iseli
Date Added: November 02, 2013  |  Visits: 238

ESTScan

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ESTScan is a program that can detect coding regions in DNA sequences, even if they are of low quality. ESTScan will also detect and correct sequencing errors that lead to frameshifts.<br /><br />ESTScan is not a gene prediction program , nor is it an open reading frame detector. In fact, its strength lies in the fact that it does not require an open reading frame to detect a coding region. As a result, the program may miss a few translated amino acids at either the N or the C terminus, but will detect coding regions with high selectivity and sensitivity.<br />Method<br /><br />ESTScan takes advantages of the bias in hexanucleotide usage found in coding regions relative to non-coding regions. This bias is formalized as an inhomogeneous 3-periodic fifth-order Hidden Markov Model (HMM). Additionally, the HMM of ESTScan has been extended to allows insertions and deletions when these improve the coding region statistics.

Requirements: No special requirements
Platforms: *nix, Linux
Keyword: Advantages Deletions Fifthorder Formalized Found Hexanucleotide Hidden Improve Inhomogeneous Insertions Markov Noncoding Periodic Relative Sensitivitymethodestscan Statistics Takes Usage
Users rating: 0/10

License: Freeware Size: 40.96 KB
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