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Ventricular guinea-pig action potential 1.0

  Date Added: July 13, 2013  |  Visits: 232

Ventricular guinea-pig action potential

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This is a Simulink Model Code of a guinea-pig ventricular action potential published byFaber GM, Silva J, Livshitz L, Rudy Y. Kinetic properties of the cardiac L-type Ca2+ channel and its role in myocyte electrophysiology: a theoretical investigation.Biophys J. 2007 92:1522-1543.The action potential is elicited by the block named Stimulus : 1 Hz is the initial condition.Initial conditions of the integrator blocks are steady-state values after 1h simulation (1Hz).Please not, that this differential system is actually an algebraic differential equation since voltage is already given by algebraic combination of the internal ionic concentrations. However it was shown when implementing the stimulus current in the ionic balance (here K+ stimulus current assignment) and using an d-de?appropriated-deOao solver (e.g. ode 45) the numerical solution of the differential equation system shows also stability in long time simulation (1h). In case of ode 15 which operates much faster long term stability is not exactly given, in this case one has to use the algebraic formulation of the model which I can also provide if requested.

Requirements: No special requirements
Platforms: Matlab
Keyword: Algebraic Balance Combination Concentrations Current Equation Faster Implementing Internal Ionic Shown Stimulus System Voltage
Users rating: 0/10

License: Freeware Size: 10 KB
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